Pharma Peeler Centrifuge (HX/GMP)

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Pharma Peeler Centrifuge (HX/GMP)

Pharma Peeler Centrifuge (HX/GMP)

The Pharma Peeler Centrifuge is designed for the efficient separation of solids and liquids in a single sealed environment, and specifically for pharmaceutical and fine chemical products.

The Pharma Peeler Centrifuge isolates and washes APIs (Active Pharmaceutical Ingredients) in a safe enclosed environment with automatic, reliable, and efficient equipment. It is the most modern and commonly used type of centrifuge for pharmaceuticals to increase production speed and capacity.

APIs are typically created in a reactor or crystallizer. The API needs to be isolated or separated from the other parts of the slurry through filtration. Filtering centrifuges are used to efficiently collect the solids and discharge the liquids, while also incorporating a washing step to increase the purity. Mechanically reducing the liquid content reduces the downstream thermal processing requirements such as drying time, thus protecting the quality of the API.

Production Cycle and Design Advantages

Typical Applications

  • Active Product Ingredients (APIs)
  • Antibiotics
  • Pharmaceutical Intermediate Products
  • High Potent Active Product Ingredients (HPAPI)
  • Vitamins
  • Amino, fatty acids
  • Steroids

Highlights

  • Ideal for pharmaceutical, Active Pharmaceutical Ingredients (APIs), and potent compound processes
  • Maximum purity of discharged products
  • Small and compact footprint
  • cGmp design for CIP and eliminates product stagnation zones
  • Laser cake detector (external to process chamber)
  • No contact between the operator and the product during operation makes it ideal for pharmaceutical synthesis products
  • Through-the-wall installation for clean rooms
  • Full access to and inspect all areas including rear of basket and shaft seal
  • Horizontal basket assures even loading of cake
  • Filter medium is easily changed and secured in the basket
  • Installation directly on the floor on anti-vibration dampers
  • FDA-approved oil lubrication for bearings on all models
  • Sizes range from 400mm (15.75 in.) diameter to 1700mm (66.9 in.) diameter

Discharge

  • Knife scraper blade fixed without use of bolts (FOD compliant)
    • Suitable for the maximum recovery of solids discharged and the protection of the discharge chute
  • Steep solids discharge chute (30° from vertical)
  • Heel removal assist with optional blow back
  • Options for solids discharge with high containment (use of continuous liner, isolator, etc.)
  • Maintenance of shaft and bearings from the rear side of the machine (service area) without contaminating the clean room

Control Options

  • Complete PLC controls with touch-screen interface
  • Switch between automatic, semi-automatic, and manual operation
  • Variable frequency drive (VRD) speed control
  • ATEX (Europe) electrical enclosures or NEC (North America)
  • Optional instrumentation integrated into the control system including oxygen monitoring, temperature, pressure, liquid feed flow, N2 purge

Cleaning

  • High-level surface finishing for the cleaning of the process zone
  • The highly effective C.I.P. system (Clean-in- Place) uses a Washing Machine Effect cycle and spray balls.
  • The C.I.P. system avoids cross-contamination between products from one campaign production to another, which makes the machine suitable for multi-purpose applications
  • Options for sterilizing include steam or Vaporized Hydrogen Peroxide (VHP system)

Machine Characteristics

  • Pressure tight to 400mm H20 (0.6 psig)
  • Inert gas purging
  • Easily replaceable endless filter cloth, thermo-welded, in polypropylene or PTFE of various weaves and sizes
  • Construction materials
    • Parts in contact with the product: all stainless steels and special alloys are available, such as AISI 316L, AISI 904L, Hastelloy, Monel, ALLOY 59, 254 SMO, NICKEL, TITANIUM, SAF 2205
    • Surface coating option: HALAR (ECTFE)
    • Elastomers: antistatic and FDA certified, Teflon ETFE, and hard rubber

Technical Services

  • Certifications, validation, FDA qualification, and construction documentation
  • Field service and technical support available
  • Mechanical and electrical parts
  • Process control and maintenance manuals
  • Mechanical and electrical upgrades

Standard Sizes and Technical Data

Centrifuge model: HX/GMP
Unit
Basket Diameter
mm
Basket Length
mm
Filtering Surface
m2
Cake Volume
liter
Max Load
kg
Max Speed
RPM
G Factor
xg
Centrifuge Weight
kg
Solid Chute Slope
°vs vertical
400/170 400 170 0.21 11 14 3000 2011 1100 30
500/220 500 220 0.35 22 28 2700 2037 2500 30
650/280 650 280 0.57 42 53 2300 1922 3700 30
850/380 850 380 1.01 90 112 1850 1626 5600 30
1030/610 1030 500 1.62 165 207 1500 1295 7600 30
1150/500 1150 500 1.81 222 278 1400 1260 9600 30
1300/610 1300 610 2.49 340 425 1200 1046 13000 30
1450/730 1450 730 3.32 485 607 1150 1072 16500 34
1600/800 1600 800 4.02 733 916 950 807 22000 36
1750/920 1750 920 5.05 991 1239 900 792 3400 36
400/170* 400 170 0.21 11 14 3000 2011 1100 30
500/220* 500 220 0.35 22 28 2700 2037 2500 30

*Pilot centrifuges – HX / GMP MODEL

The smaller machines are considered pilot centrifuges and are used for both research and development laboratories, as well as small productions of high-added value products. These machines, while smaller, have the same features as the industrial scale module plus can be skid mounted for easier mobility.