Inverting Filter Centrifuge (HT/GMP)

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Inverting Filter Centrifuge (HT/GMP)

Inverting Filter Centrifuge (HT/GMP)

The Inverting Filter Centrifuge is the most versatile industrial centrifuge for Active Pharmaceutical Ingredients (APIs), pharmaceutical, and fine chemical processes.

The Inverting Filter Centrifuge is used for Solid Liquid Separation within the API (Active Pharmaceutical Ingredient), pharmaceutical, and chemical industries. Specifically, it is automatic, reliable, and it isolates and washes APIs (Active Pharmaceutical Ingredients) in a safe enclosed environment.

APIs are typically created in a reactor or crystallizer. The API needs to be isolated or separated from the other parts of the slurry through filtration. Filtering centrifuges are used to efficiently collect the solids and discharge the liquids while also incorporating a washing step to increase purity. Mechanically reducing the liquid content reduces the downstream thermal processing requirements such as drying time, thus protecting the quality of the API.

Reserved for challenging products, the inverting centrifuge provides the highest recovery with the most advanced design. If your product is too sticky, compressible, difficult to discharge, or you still need to reach a lower moisture content after trying other centrifuges, then it is time to move toward a more complicated design that can solve your problem.

Production Cycle and Design Advantages

Typical Applications

  • Pharmaceutical and fine chemical products
  • Active Pharmaceutical Ingredients (APIs)
  • Pharmaceutical intermediate products
  • High Potent Active Products (HPAPI)
  • Pharmaceutical synthesis products

Highlights

  • Ideal for slow filtering and compressible products
  • High separation efficiency for products with fine particles, compressible products (low filterability), and fine chemical/API (Active Pharmaceutical Ingredients)
  • No residual heel
  • Gentle product discharge
  • Hyper centrifugation available for fixed bed drying
  • 100% access to solids and filtrate housing
  • No contact between the operator and product during operation makes it ideal for the production of pharmaceutical synthesis products
  • Sizes range from 300mm (11.8 in.) diameter to 1000mm (39.4 in.) diameter – See charts below
  • Inertia pad with dampers allows installation directly on the floor
  • Through-the-wall installation for clean rooms
  • Even cake distribution due to the horizontal design

Discharge

  • Gently handles crystals: the solids discharge is achieved by means of filter cloth inversion (reversible bag), allowing soft crystals to be recovered without breaking
  • Electromechanical filter cloth inversion (oil-free execution)
  • The short discharge time and complete elimination of the heel cake at every cycle result in high yield. Ultra-thin cakes can be processed efficiently. Even products with low filtering properties (those with fine particles and high compressibility) can be separated, resulting in uniform cake washing.
  • Various levels of containment options are available for solids discharge

Control Options

  • Complete PLC controls with touch-screen interface
  • Switch between automatic and manual operation
  • Variable frequency drive (VRD) speed control
  • ATEX (Europe) electrical enclosures or NEC (North America)
  • Optional instrumentation integrated into the control system including oxygen monitoring, temperature, pressure, liquid feed flow, and N2 purge

Cleaning

  • Its highly effective C.I.P. system (Clean-in- Place) uses a W.M.E. (Washing Machine Effect) and spray balls
  • Removal of bound moisture is achieved by dry or heated gas at up to 6 barg differential pressure across the cake (Hyperbaric Centrifugation System – HCS)
  • The front casing can be fully opened, allowing the process area to be completely inspected

Machine Characteristics

  • Cake volumes from 7 (pilot unit) to 210 liters – See charts below
  • High G factors from 1018 to 1663 (pilot unit) – See charts below
  • Basket load setting via load cell system
  • Filter cloths available in polypropylene, HALAR, or PTFE
  • Gas tightness at 400 mm H2O
  • High surface finishes
  • Complete FDA validation documentation
  • Construction materials
    • Parts in contact with the product: all stainless steels and special alloys are available, such as AISI 316L, AISI 904L, hastelloy, monel, alloy 59, 254 SMO, nickel, titanium, and SAF 2205
    • Surface coating option: Halar (ECTFE)
    • Elastomers: antistatic and FDA certified, Teflon ETFE, and hard rubber

Technical Services

  • Field service and technical support available
  • Mechanical and electrical parts
  • Process control and maintenance manuals
  • Certifications and construction documentation
  • Mechanical and electrical upgrades

Standard Sizes and Technical Data

Centrifuge model: HX/GMP
Unit
Basket Diameter
mm
Basket Length
mm
Filtering Surface
m2
Cake Volume
liter
Slurry Density
kg/dm2
Max Load
kg
Max Speed
RPM
G Factor
xg
Centrifuge Weight
kg
300/110 300 110 0.1 7 1.25 9 3150 1663 1400
470/180 470 180 0.27 27 1.25 34 2300 1390 3000
600/225 600 225 0.45 52 1.25 65 2000 1340 4000
700/225 700 225 0.52 65 1.25 81 1850 1338 4600
800/350 800 350 0.90 122 1.25 152 1600 1144 8500
900/350 900 350 1 145 1.25 181 1500 1131 8700
1000/430 1000 430 1.35 210 1.25 262 1350 1018 9400
300/110* 300 110 0.1 7 1.25 9 3150 1663 1400
470/180* 470 180 0.27 27 1.25 34 2300 1390 3000

*Pilot Centrifuges

The smaller machines are considered pilot centrifuges and are used for both research and development laboratories, as well as small productions of high-added value products. These machines, while smaller, have the same features as the industrial scale module plus can be skid mounted for easier mobility.

Check out our other filtering centrifuge solutions.